They can, but as the owner you don't want to do it that way.
If each manager sets up their own business, then as the owner you will not have access to the control center and you will not be able view any appointment activity at your various locations.
Take the time to set up each business using your own membership. Once each business is set then assign a manager to it. This way you will be able to monitor all appointment activity at each of your business locations.
